NOT KNOWN DETAILS ABOUT NAD+ AND ITS ROLE IN MITOCHONDRIAL FUNCTION

Following, we handled cells with various concentrations of NAD+. When included for 24 h at eighty µM in HeLa and four hundred µM in U2OS cells, NAD+ impaired the incorporation of EdU (Fig. 2a and Extended Knowledge Fig. 1k,l). Additionally, sixteen µM of NAD+ was sufficient to scale back fork speed by ~40% in HeLa cells without affecting